ABSTRACT
Background: An adverse blood transfusion reaction (ABTR) is an unfavorable, unwanted reaction to the transfused unit. It may be acute or delayed , immune or non immune and infections . Materials and methods A study was conducted to detect the frequency of various ABTRs (both immunologic and &infections) and associated morbidity in a surgical oncology tertiary care centre for the past 2 years. Results: A total 7823 units of blood and blood components was issued for entire hospital, out of these 1120 units of blood and blood products was transfused in surgical oncology department over a period of two years. In these transfusions one patient(0.89%) was developed ABTR for that transfusion immediately stopped. A total 30patients (2.67%) developed minor transfusion related reaction that was managed with antihistamine and steroids. The most common adverse event was allergic reactions –20/30(66.6%) followed by feile episodes – 10/30(33.3%). We noticed that out of 27 recently positive hepatitis virus patients 7 patients had previous blood transfusion history. Within the 7 patients 6 patients also received chemotherapy and 1 patient had previous history of surgery. Conclusion : The most common adverse reactions to blood transfusions reported here are allergic reactions and feile episodes. Clerical error is the commonest cause for mismatch transfusion. Hepatitis B&C virus may be transmitted during window period. It can be prevented by using nucleic acid tests (NAT) as screening tests to prevent window period transmission.
ABSTRACT
Objective To analyze the causes of blood transfusion adverse reactions in children,and to explore the measures to reduce the adverse reactions of blood transfusion in children.Methods Collect 30 518 cases of transfusion reaction data which is during 2009 to 2014 in Kunming Children's hospital for analyzing.Results 166 cases of transfusion reaction occurred and the occurrence rate is 0.54％ in 30 518 cases,allergic transfusion reaction accounted for 89.16％ (148/166),non-hemolytic febrile reaction 10.24 ％ (17/166),hemoglobinuria accounted for 0.60 ％ (1/166);In children the transfusion reaction rate of hemapheresis platelet is 1.92％(72/3 743),plasma is 0.43％(56/13 132),suspension red blood cells is 0.28％(38/13 480);the signs and symptoms of children's blood transfusion reaction:simplex urticaria and rash 74.10％(123/166),simplex fever 10.24％ (17/166),rash associated with fever 5.42％ (9/166),eyelid or oral edema (mild angioneurotic oedema) 9.04％ (15/166),,Bronchospasm (mild) 0.60％ (1/166),simple hemoglobinuria 0.60％ (1/166).Conclusion Children with blood transfusion adverse reactions to allergies,mainly for local or systemic rash;Platelet is the most-common blood component that causes transfusion reaction with children.